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Table 3 Expected variation in positive predictive value (i.e. probability that a case meeting the diagnostic criteria is truly ill with COVID-19) by COVID-19 incidence

From: Considerations for planning COVID-19 treatment services in humanitarian responses

COVID-19 incidence Background incidence of diseases with overlapping signs and symptoms (consider the patient’s age and comorbidities, the geographic setting and season) Modality of COVID-19 diagnosis
Testing Syndromic
High
(around the peak)
Low Very high High
High Very high Low to moderate (for mild and moderate cases)
Moderate to high (for severe cases)
Medium
(just after or just before the peak)
Low Very high Moderate to high
(for mild and moderate cases)
High
(for severe cases)
High High Moderate
(for mild and moderate cases)
Moderate to high
(for severe cases)
Low
(early or late in the epidemic)
Low High Low to moderate (for mild and moderate cases)
Moderate to high (for severe cases)
High Moderate to high (depends on test specificity) Very low (for mild and moderate cases)
Low (for severe cases)
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